Endocrine Abstracts

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a highly heterogeneous disorder and is the cause of <2% of cases of Cushing’s syndrome. Around 20-25% of patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) have a mutation in ARMC5.Case report: 47 year old gentleman was incidentally found to have bilateral adrenal lesions when he had a CT scan of his chest performed for chest and back pains. He had ...

A 23-year-old female with severe resistant hypertension was referred to our Hospital. Her BP on arrival was 240/140 mmHg and she was 13 weeks pregnant. Labetalol had been prescribed previously (200 mg,TDS), with little success in controlling her symptoms. The patient reported headaches, migraines and flushing for several years, especially after eating, and worse during pregnancy. The patient had pre-eclampsia in her first pregnancy.<p class="abst...

A 23-year-old female with severe resistant hypertension was referred to our Hospital. Her BP on arrival was 240/140 mmHg and she was 13 weeks pregnant. Labetalol had been prescribed previously (200 mg,TDS), with little success in controlling her symptoms. The patient reported headaches, migraines and flushing for several years, especially after eating, and worse during pregnancy. The patient had pre-eclampsia in her first pregnancy.<p class="abst...

Background: Adrenal incidentaloma (AI) increasingly pose a diagnostic challenge. This retrospective observational study evaluated biochemical investigations performed in patients referred to Endocrine Surgery with AI and assessed adherence to Guidelines. Biochemical, histological and radiological characteristics of AI were also reviewed.Methods: Data were collected from Hospital and Laboratory records for referrals between January 2012–April 2014.</...

Backgound: We report a case of a 63-year-old postmenopausal female diagnosed with ovarian hyperthecosis masked by concurrent use of an aromatase inhibitor.Following diagnosis of breast cancer in 2009, requiring mastectomy with adjunctive chemotherapy, she was commenced on anastrozole. Later she noted gradual onset of frontal balding and hirsutism. Biochemistry revealed elevated serum levels of testosterone 13.2 nmol/l (range: <1.9 nmol/l) and androst...

Introduction: Clinical Practice Guidelines1 advocate adrenal vein sampling (AVS) to distinguish between unilateral and bilateral primary aldosteronism (PA). Cannulating the right adrenal vein is difficult, and there is a lack of standardisation in sampling procedure and interpretation2. We audited our local service to identify improvements.Methods: All AVS procedures performed between January 2018-December 2020 (n = 31) wer...

Introduction: Activating mutations in thyrotropin receptor (TSHR) have been previously described in the context of non-autoimmune hyperthyroidism (familial or sporadic) and thyroid adenomas. We describe, for the first time, a mutation in TSHR contributing to follicular thyroid carcinoma (FTC) in an adolescent girl.Case: A 12-year-old girl presented with a right-sided neck swelling, increasing in size over the previous four weeks. Clinic...